This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (108)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Alberto DiMascio, PhD; Diosdado L. Bernardo, MD; David J. Greenblatt, MD; Joseph E. Marder, RPh

Arch Gen Psychiatry. 1976;33(5):599-602.

Abstract
• Presently marketed antiparkinsonism drugs are potent anticholinergic agents that, while effective in treating extrapyramidal symptoms (EPS), also are productive of or can exacerbate a number of side effects associated with psychotropic drugs. Some of these include gastrointestinal disturbances, visual difficulties, and tardive dyskinesia.

A double-blind study was carried out to assess the efficacy (and adverse effects) of amantadine hydrochloride—an agent without appreciable anticholinergic activity—for the treatment of drug-induced EPS.

Amantadine was found to be comparable in effect to benztropine mesylate, but with fewer side effects. The potential role of amantadine may be in the treatment of patients with druginduced EPS for whom medication with anticholinergic properties is contraindicated.

Author Affiliations
From the Department of Mental Health, Commonwealth of Massachusetts (Dr DiMascio and Mr Marder), Tufts University School of Medicine (Dr DiMascio), Boston, Foxborough (Mass) State Hospital (Dr Bernardo), Massachusetts General Hospital, and Harvard Medical School, Boston (Dr Greenblatt).

Footnotes
Accepted for publication Dec 5, 1975.

Reprint requests to 591 Morton St, Boston, MA 02124 (Dr DiMascio).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Predictor Index of Mortality in Dementia Patients Upon Entry Into Long-term Care
Carlson et al.
Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2001;56:M567-570.
ABSTRACT | FULL TEXT  

Treatment of Inhalant-Induced Psychotic Disorder With Carbamazepine Versus Haloperidol
Hernandez-Avila et al.
Psychiatr. Serv. 1998;49:812-815.
ABSTRACT | FULL TEXT  

Serum Levels of Anticholinergic Drugs in Treatment of Acute Extrapyramidal Side Effects
Tune and Coyle
Arch Gen Psychiatry 1980;37:293-297.
ABSTRACT