This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Lance L. Simpson, MD

Arch Gen Psychiatry. 1976;33(6):691-695.

Abstract
• Blood pressure responses to amphetamine have been studied both in humans and in rats. Blood pressure was monitored In patients who had experienced an adverse behavioral reaction to the drug. All of the patients had self-administered amphetamine, and later sought medical attention for their adverse reaction. In a series of 14 patients, there was no evidence that amphetamine had evoked a sustained increase in blood pressure.

In rats, experiments were conducted in two steps: (1) a determination of the doses of amphetamine that cause behavioral stimulation, and (2) an evaluation of the blood pressure effects of the same doses of amphetamine. In control animals, behavioral stimulant doses of amphetamine exerted only transient effects on blood pressure. In pithed animals, ie, animals devoid of all central mechanisms, amphetamine exerted a sustained effect on blood pressure. It is concluded that the potential ability of amphetamine to evoke sustained cardiovascular responses is damped by the central nervous system of intact animals.

Author Affiliations
From the Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York.

Footnotes
Accepted for publication Feb 2,1975.

Read in part before the World Congress of Biological Psychiatry, Buenos Aires, Sept 24, 1974.

Reprint requests to Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032 (Dr Simpson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Environmental Novelty Differentially Affects c-fos mRNA Expression Induced by Amphetamine or Cocaine in Subregions of the Bed Nucleus of the Stria Terminalis and Amygdala
Day et al.
J. Neurosci. 2001;21:732-740.
ABSTRACT | FULL TEXT  

Methylphenidate vs Dextroamphetamine vs Caffeine in Minimal Brain Dysfunction: Controlled Comparison by Placebo Washout Design With Bayes' Analysis
Arnold et al.
Arch Gen Psychiatry 1978;35:463-473.
ABSTRACT