Methadyl acetate and methadone as maintenance treatments for heroin addicts. A veterans administration cooperative study
W. Ling, C. Charuvastra, S. C. Kaim and C. J. Klett
This was a double-blind comparison of methadyl acetate and two dose levels
of methadone hydrochloride in the maintenance of 430 street heroin addicts
from 12 Veterans Administration hospitals. The starting sample consisted of
146 patients receiving low-dose methadone, 142 patients receiving methadyl
acetate. Patients were first given 30 mg of both drugs, and doses were
incremented by 10 mg/week until they stabilized at methadyl acetate, 80 mg
three times a week, and methadone hydrochloride, 50 mg daily or 100 mg
daily. Dosage was fixed for the balance of the 40-week treatment period.
Safety was evaluated by clinical and laboratory observations conducted at
frequent intervals throughout the study. Relative efficacy was evaluated by
illicit drug use, program retention and attendance, and global staff
judgments. It is concluded that methadyl acetate is as safe a drug as
methadone and that it compares favorably with highdose methoadone in terms
of efficacy. Both methyadyl acetate and high-dose methadone appear to be
better maintenance regimens than low-dose methadone under the conditions of
this study.
Medication Development for Addictive Disorders: The State of the Science
Vocci et al.
Am. J. Psychiatry 2005;162:1432-1440.
ABSTRACT
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Methadone: applied pharmacology and use as adjunctive treatment in chronic pain
Brown et al.
Postgrad. Med. J. 2004;80:654-659.
ABSTRACT
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The Gap Between Research and Practice in Substance Abuse Treatment
Marinelli-Casey et al.
Psychiatr. Serv. 2002;53:984-987.
ABSTRACT
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A Comparison of Levomethadyl Acetate, Buprenorphine, and Methadone for Opioid Dependence
Johnson et al.
NEJM 2000;343:1290-1297.
ABSTRACT
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Pharmacologic Treatment of Heroin-Dependent Patients
O'Connor and Fiellin
ANN INTERN MED 2000;133:40-54.
ABSTRACT
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Relative Potency of levo-alpha -Acetylmethadol and Methadone in Humans under Acute Dosing Conditions
Eissenberg et al.
J. Pharmacol. Exp. Ther. 1999;289:936-945.
ABSTRACT
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Moderate- vs High-Dose Methadone in the Treatment of Opioid Dependence: A Randomized Trial
Strain et al.
JAMA 1999;281:1000-1005.
ABSTRACT
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Therapeutic Alliance and Psychiatric Severity as Predictors of Completion of Treatment for Opioid Dependence
Petry and Bickel
Psychiatr. Serv. 1999;50:219-227.
ABSTRACT
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Induction With Levomethadyl Acetate: Safety and Efficacy
Jones et al.
Arch Gen Psychiatry 1998;55:729-736.
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Clinical trials in psychiatry: background and statistical perspective
Johnson
Stat Methods Med Res 1998;7:209-234.
ABSTRACT
Intravenous and Oral l-alpha -Acetylmethadol: Pharmacodynamics and Pharmacokinetics in Humans
Walsh et al.
J. Pharmacol. Exp. Ther. 1998;285:71-82.
ABSTRACT
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The Involvement of Cytochrome P450 3A4 in the N-Demethylation of l-alpha -Acetylmethadol (LAAM), norLAAM, and Methadone
Moody et al.
Drug Metab. Dispos. 1997;25:1347-1353.
ABSTRACT
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Fortnightly Review: Methadone maintenance treatment in opiate dependence: a review
Farrell et al.
BMJ 1994;309:997-1001.
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