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Baron Shopsin, MD; Eitan Friedman, PhD; Samuel Gershon, MD

Arch Gen Psychiatry. 1976;33(7):811-819.

Abstract
• Hospitalized bipolar and unipolar endogenously depressed patients who showed an antidepressant response to the monoamine oxidase (MAO) inhibitor, tranylcypromine sulfate, relapsed (ie, depression returned) when relatively small doses of parachlorophenylalanine (PCPA) were added for brief periods. Considered together with our findings that PCPA similarly reversed the antidepressant effects of the tricyclic drug, imipramine hydrochloride, implications are (1) serotonergic mechanisms are likely involved in the antidepressant effects of both the tricyclic drugs and MAO inhibitors in man and (2) this indolamine may also play a role in the endogenous clinical state of depression.

Author Affiliations
From the Neuropsychopharmacology Research Unit, Department of Psychiatry, New York University Medical Center.

Footnotes
Accepted for publication Jan 19, 1976.

Read in part before the First Pacific Congress of Psychiatry, Melbourne, May 11 to 16, 1975.

Reprint requests to Neuropsychopharmacology Research Unit, Department of Psychiatry, New York University Medical Center, 550 First Ave, New York, NY 10016 (Dr Shopsin).

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