Cardiovascular and subjective effects of intravenous cocaine administration in humans
M. W. Fischman, C. R. Schuster, L. Resnekov, J. F. Shick, N. A. Krasnegor, W. Fennell and D. X. Freedman
Nine volunteer subjects were tested with intravenously administered cocaine
hydrochloride in doses ranging from 4 to 32 mg, as well as 10 mg of
dextroamphetamine sulfate. Measures of cardiovascular and subjective
effects were made. Generally parallel dose-effect functions were obtained
for heart rate, blood pressure, Addiction Research Center Inventory scores,
Profile of Mood Scales, and subject ratings. A substantial effect on each
of these variables was recorded after 8 mg of cocaine. The increase
continued and peaked at approximately 16 mg after which it usually leveled
off. Ten milligrams of dextroamphetamine generally had an effect comparable
to 8 to 16 mg of cocaine.
An ion channel 'addicted' to ether, alcohol and cocaine: the HERG potassium channel
Karle and Kiehn
Cardiovasc Res 2002;53:6-8.
FULL TEXT
Inhibition of HERG potassium channels by cocaethylene: a metabolite of cocaine and ethanol
O'Leary
Cardiovasc Res 2002;53:59-67.
ABSTRACT
| FULL TEXT
Attenuation of the Euphoric Effects of Cocaine by the Dopamine D1/D5 Antagonist Ecopipam (SCH 39166)
Romach et al.
Arch Gen Psychiatry 1999;56:1101-1106.
ABSTRACT
| FULL TEXT
Ambient Temperature and Mortality From Unintentional Cocaine Overdose
Marzuk et al.
JAMA 1998;279:1795-1800.
ABSTRACT
| FULL TEXT
Time of Onset of Necrotizing Enterocolitis in Newborn Infants with Known Prenatal Cocaine Exposure
Lopez et al.
CLIN PEDIATR 1995;34:424-429.
ABSTRACT
ETHNOPHARMACOLOGY: An Interdisciplinary Approach to the Study of Intravenous Drug Use and HIV
JOHNSON
Journal of Contemporary Ethnography 1990;19:349-369.
ABSTRACT
Ice: A New Dosage Form of an Old Drug
Cho
Science 1990;249:631-634.
ABSTRACT
Cocaine plasma concentration: relation to physiological and subjective effects in humans
Javaid et al.
Science 1978;202:227-228.
ABSTRACT
Choice behavior in rhesus monkeys: cocaine versus food
Aigner and Balster
Science 1978;201:534-535.
ABSTRACT
Oral cocaine: plasma concentrations and central effects
Van Dyke et al.
Science 1978;200:211-213.
ABSTRACT
Acute systemic effects of cocaine in man: a controlled study by intranasal and intravenous routes
Resnick et al.
Science 1977;195:696-698.
ABSTRACT
