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Marian W. Fischman, PhD; Charles R. Schuster, PhD; Leon Resnekov, MD; J. Fred E. Shick, MD; Norman A. Krasnegor, PhD; William Fennell, MD; Daniel X. Freedman, MD

Arch Gen Psychiatry. 1976;33(8):983-989.

Abstract
• Nine volunteer subjects were tested with intravenously administered cocaine hydrochloride in doses ranging from 4 to 32 mg, as well as 10 mg of dextroamphetamine sulfate. Measures of cardiovascular and subjective effects were made. Generally parallel dose-effect functions were obtained for heart rate, blood pressure, Addiction Research Center Inventory scores, Profile of Mood Scales, and subject ratings. A substantial effect on each of these variables was recorded after 8 mg of cocaine. The increase continued and peaked at approximately 16 mg after which it usually leveled off. Ten milligrams of dextroamphetamine generally had an effect comparable to 8 to 16 mg of cocaine.

Author Affiliations
From the departments of psychiatry (Drs Fischman, Schuster, Shick, and Freedman), pharmacological and physiological sciences (Dr Schuster), and medicine (Drs Resnekov, and Fennell), University of Chicago, Pritzker School of Medicine, and the National Institute on Drug Abuse (Dr Krasnegor), Rockville, Md.

Footnotes
Accepted for publication March 25, 1976.

Reprint requests to Department of Psychiatry, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr Fischman).

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