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Peter E. Stokes, MD; James H. Kocsis, MD; Orestes J. Arcuni, MD

Arch Gen Psychiatry. 1976;33(9):1080-1084.

Abstract
• Three separate lithium chloride doses, calculated according to body weight, and a placebo were administered under doubleblind conditions to 68 manic inpatients. The relationship of lithium chloride treatment dose to steady-state serum lithium levels (day 7 to 10 of treatment) and clinical response were examined.

High (0.72 mEq/kg/day) and medium (0.5 mEq/kg/day) lithium chloride doses were more efficacious than placebo (P <.001 and p <.05, respectively), as determined by decrements in global mania ratings (day 7 to 10 of treatment). A low dose (0.24 mEq/kg/day) was not found to be more efficacious than placebo.

The proportion of patients with improved manic ratings increased markedly as a function of increased steady-state serum lithium level (x2 for trend in proportions, 17.91; p <.001).

Author Affiliations
From the Payne Whitney Clinic, New York Hospital-Cornell Medical Center, New York.

Footnotes
Accepted for publication Feb 16, 1976.

Reprint requests to Payne Whitney Clinic, 525 E 68th St, New York, NY 10021 (Dr Kocsis).

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