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Gerald W. Vogel, MD; Robert McAbee; Katherine Barker; Arthur Thurmond

Arch Gen Psychiatry. 1977;34(1):96-97.

Abstract
• In the treatment of endogenous depression by rapid eye movement (REM) sleep deprivation, depression improvement, measured on Hamilton and Global scales, correlated positively and significantly (P <.05) with REM pressure (increase of REM sleep stimulated by REM sleep deprivation). This dose-response relationship suggests that (1) REM pressure was an indicator of a process that mediated the antidepressant effects of REM sleep deprivation, and (2) since improvement varied with stimulation of REM sleep, an unknown stimulus of REM sleep is a naturally occurring, endogenous antidepressant.

Author Affiliations
From the Georgia Mental Health Institute and the Department of Psychiatry, Emory University, Atlanta.

Footnotes
Accepted for publication June 16, 1976.

Reprint requests to Sleep Laboratory, Georgia Mental Health Institute, 1256 Briarcliff Rd NE, Atlanta, GA 30306 (Dr Vogel).

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ABSTRACT