This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

David S. Janowsky, MD; Leighton Huey, MD; Lowell Storms, PhD; Lewis L. Judd, MD

Arch Gen Psychiatry. 1977;34(2):189-194.

Abstract
— Actively psychotic schizophrenic and nonpsychotic psychiatric inpatients received intravenous methylphenidate hydrochloride (0.5 mg/kg). Each patient was rated for level of psychosis and talkativeness, and each received the Holtzman projective ink blot tests and the Kent-Rosanoff word-association tests before, during, and after methylphenidate infusion. Minnesota Multiphasic Personality Inventory Goldberg Index scores were also obtained as a general measure of psychosis. For the entire patient group, methylphenidate infusion was followed by a significant increase in talkativeness and psychosis ratings and in pathological responses to the Holtzman ink blot test. There was a significant decrease in common word associations. Since neither of the psychological tests allow more than one response per item, it appears that methylphenidate truly effects pathological thought processes and decreases common word associations as such, rather than merely making these processes more evident by increasing verbalization.

Author Affiliations
From the Department of Psychiatry, University of San Diego School of Medicine, La Jolla, Calif.

Footnotes
Accepted for publication Oct 18, 1976.

Reprint requests to the Department of Psychiatry, University of San Diego School of Medicine, La Jolla, CA 92037 (Dr Janowsky).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Stimulant psychosis: systematic review
Curran et al.
Br. J. Psychiatry 2004;185:196-204.
ABSTRACT | FULL TEXT  

Long-term Pimozide Pretreatment Differentially Affects Behavioral Responses to Dextroamphetamine in Schizophrenia: Further Exploration of the Dopamine Hypothesis of Schizophrenia
van Kammen et al.
Arch Gen Psychiatry 1982;39:275-281.
ABSTRACT  

The Therapeutic Community as a Research Ward: Myths and Facts
Braff et al.
Arch Gen Psychiatry 1979;36:355-360.
ABSTRACT  

The Effect of Methylphenidate on Serum Growth Hormone: Influence of Antipsychotic Drugs and Diagnosis
Janowsky et al.
Arch Gen Psychiatry 1978;35:1384-1389.
ABSTRACT