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Solomon H. Snyder, MD; Henry I. Yamamura, PhD

Arch Gen Psychiatry. 1977;34(2):236-239.

Abstract
• Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.

Author Affiliations
From the Departments of Pharmacology and Experimental Therapeutics and Psychiatry and the Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore.

Footnotes
Accepted for publication April 7, 1976.

Reprint requests to Department of Pharmacology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205 (Dr Snyder).

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