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II. Perinatal Factors and IQ

Ronald O. Rieder, MD; Sarah H. Broman, PhD; David Rosenthal, PhD

Arch Gen Psychiatry. 1977;34(7):789-799.

Abstract
• Within a sample of 60 children of schizophrenic parents, IQ and the correlates of IQ were examined. The Wechsler intelligence Scale for Children was administered at age 7. The offspring of parents with schizophrenia were found to have a slightly lower IQ than their matched controls. This deficit could be attributed entirely to the male offspring.

Using a second comparison group numbering several thousand, we computed correlations for various perinatal and socioeconomic factors with seven-year IQ. These correlations were also computed for the children of schizophrenics, and the difference in correlations was examined. iQs for the offspring of "continuous schizophrenics" (chronic, borderline, and chronic schizo-affective schizophrenics) were found to have lower correlations with socioeconomic indices and higher correlations, in a negative direction, with certain perinatal events. The findings were found to a lesser, nonsignificant degree among the small sample of offspring of acute schizophrenics. If these perinatal events are more negatively correlated with IQ because the children of continuous schizophrenics are specifically susceptible to them, it is possible that these factors are also influential in the later development of schizophrenia.

Author Affiliations
From the Laboratory of Psychology and Psychopathology, Intramural Research Program, National Institute of Mental Health (Drs Rieder and Rosenthal), and the Perinatal Research Branch, National Institute of Neurological and Communicative Disorders and Stroke (Dr Broman), Bethesda, Md.

Footnotes
Accepted for publication Feb 14, 1977.

Read in part before the 128th annual meeting of the American Psychiatric Association, Anaheim, Calif, May 5-9, 1975.

Reprint requests to Laboratory of Psychology and Psychopathology, Intramural Research Program, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20014 (Dr Rieder).

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