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Psychoses Precipitated by Psychotomimetic DrugsA Follow-up Study
Malcolm B. Bowers, Jr, MD
Arch Gen Psychiatry. 1977;34(7):832-835.
Abstract
• Fifteen patients who developed prolonged psychotic reactions following psychotomimetic drug use (probably primarily LSD) were followed up 1.9 to 5.8 years later. Two patients had committed suicide. Approximately half of the patients had a relatively good outcome and half did poorly. Aspects of the initial clinical picture that correlated with outcome measures are discussed. The possibility is considered that vulnerability to a prolonged psychotic reaction following psychotomimetic drug use may be related to a genetic vulnerability to illnesses in the manic-depressive/schizo-affective spectrum. In some instances this vulnerability may implicate central serotonergic neuronal systems.
Author Affiliations
From the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn.
Footnotes
Accepted for publication Sept 29, 1976.
Reprint requests to Department of Psychiatry, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510 (Dr Bowers).
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