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Alan J. Gelenberg, MD; Michel R. Mandel, MD

Arch Gen Psychiatry. 1977;34(8):947-950.

Abstract
• Eight patients developed a syndrome marked by features of catatonia (including posturing, waxy flexibility, withdrawal and regression) and parkinsonism (including bradykinesia and rigidity) while receiving high-potency neuroleptic drugs. The syndrome had a gradual onset, responded slowly to withdrawal of the neuroleptic or use of an anticholinergic agent, but seemed to respond more rapidly to amantadine. The syndrome may easily be confused with a worsening of schizophrenic symptoms.

Author Affiliations
From the Special Studies Clinic, Department of Psychiatry, Massachusetts General Hospital, Erich Lindemann Mental Health Center, and Harvard Medical School, Boston.

Footnotes
Accepted for publication Feb 16, 1976.

Reprint requests to Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114 (Dr Gelenberg).

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