This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Associations With Hematologic Malignancy and Down's Syndrome

Leonard L. Heston, MD; Angeline R. Mastri, MD

Arch Gen Psychiatry. 1977;34(8):976-981.

Abstract
• Relatives of probands with histologically confirmed Alzheimer's disease had excessive morbidity from Alzheimer's disease, Down's syndrome, and hematologic malignancies. These associations coupled with two previously reported ones, the indistinguishable histopathological changes in brain in Alzheimer's disease and Down's syndrome, and the 20-fold increased incidence of leukemia among persons with Down's syndrome, are evidence that some instances of those disorders are associated with a unitary genetic etiology. The genetic defect may be expressed through disorganization of microtubules. Other evidence suggests that the same process may be involved in aging and in other chromosomal aberrations.

Author Affiliations
From the Departments of Psychiatry (Dr Heston) and Neurology and Pathology (Dr Mastri), University of Minnesota, Minneapolis.

Footnotes
Accepted for publication Dec 1, 1976.

Reprint requests to Box 392 Mayo, University of Minnesota, Minneapolis, MN 55455 (Dr Heston).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Constitutional Aneuploidy in the Normal Human Brain
Rehen et al.
J. Neurosci. 2005;25:2176-2180.
ABSTRACT | FULL TEXT  

The Schizophrenia Phenotype in 22q11 Deletion Syndrome
Bassett et al.
Am. J. Psychiatry 2003;160:1580-1586.
ABSTRACT | FULL TEXT  

Early-onset Alzheimer's disease in Scotland: environmental and familial factors
WHALLEY
Br. J. Psychiatry 2001;178 :s53-s59.
ABSTRACT | FULL TEXT  

The Role of Presenilin 1 in the Genetics of Alzheimer's Disease
Clark et al.
Cold Spring Harb Symp Quant Biol 1996;61:551-558.
ABSTRACT  

Molecular Genetics of Alzheimer's Disease
Clark and Goate
Arch Neurol 1993;50:1164-1172.
ABSTRACT  

A Family-Genetic Study of Dementia of Alzheimer Type
Martin et al.
Arch Gen Psychiatry 1988;45:894-900.
ABSTRACT  

Research in Alzheimer's disease: A progress report
Moss
AM J ALZHEIMERS DIS OTHER DEMEN 1988;3:10-16.
 

The Complete Dementia Evaluation: Complications and Complexities
Ashford et al.
AM J ALZHEIMERS DIS OTHER DEMEN 1987;2:9-15.
 

Resolution: The Final Life Task
Feil
Journal of Humanistic Psychology 1985;25:91-105.
ABSTRACT  

A Family With Histologically Confirmed Alzheimer's Disease
Nee et al.
Arch Neurol 1983;40:203-208.
ABSTRACT  

Posttraumatic Premature Alzheimer's Disease: Neuropathologic Findings and Pathogenetic Considerations
Rudelli et al.
Arch Neurol 1982;39:570-575.
ABSTRACT  

Dementia of the Alzheimer Type: Clinical Genetics, Natural History, and Associated Conditions
Heston et al.
Arch Gen Psychiatry 1981;38:1085-1090.
ABSTRACT