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Gordon F. S. Johnson, MB, BS, FANZCP, MRCPsych, DPM; Marsha M. Leeman

Arch Gen Psychiatry. 1977;34(9):1074-1083.

Abstract
• Familial transmission of affective illness was studied using a family interview and family history method in a group of 35 bipolar manic-depressive patients. Morbidity risk for bipolar and unipolar affective illness in first-degree relatives is approximately 30% in this population. Probands with a positive family history for bipolar illness have a significantly greater risk for alcoholism in first-degree relatives. Four cases of father-to-son transmission are reported. Linkage of color vision deficiency or Xg blood group and affective illness within families could not be substantiated in our sample. We discuss evidence regarding the mode of transmission of affective illness.

Author Affiliations
From the Department of Psychiatry, University of Sydney, Australia.

Footnotes
Accepted for publication Feb 25, 1977.

Reprint requests to Department of Psychiatry, University of Sydney, New South Wales, Australia 2006 (Dr Johnson).

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