 |
|
Prolactin Responses to Neuroleptics in Normal and Schizophrenic Subjects
Peter H. Gruen, MD;
Edward J. Sachar, MD;
Gerhard Langer, MD;
Norman Altman, MD;
Marvin Leifer, MD;
Andrew Frantz, MD;
Frieda S. Halpern, MA
Arch Gen Psychiatry. 1978;35(1):108-116.
Abstract
• The prolactin response to neuroleptics can serve as an index of dopamine blockade in humans. Plasma prolactin increments to single doses of chlorpromazine, and prolactin decrements to single doses of levodopa, were similar in normal and schizophrenic subjects. Antischizophrenic drugs of all chemical classes stimulated prolactin release, while chemically related drugs and other psychotropic agents ineffective in schizophrenia did not. The prolactin response to neuroleptic therapy occurred in all patients, and tolerance did not develop. Within subjects, prolactin responses were graded according to neuroleptic dose, but the upper limit of sensitivity of the response curve was achieved at doses below the therapeutic range. Relative prolactin-stimulating potency in humans of chlorpromazine, thioridazine, trifluoperazine, butaperazine, and haloperidol correlated well with their relative clinical potencies.
Author Affiliations
From the Departments of Psychiatry, Albert Einstein College of Medicine and Columbia University College of Physicians and Surgeons, New York.
Footnotes
Accepted for publication Aug 24, 1977.
Read in part before the American Psychopathological Association, New York, March 1975, and the American College of Neuropharmacology, Puerto Rico, December 1975.
Reprint requests to Department of Psychiatry, Columbia University, 722 W 168th St, New York, NY 10032 (Dr Sachar).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Evaluating Prolactin Response to Dopamine Agonists in Schizophrenia: Methodological Problems
Davis et al.
Arch Gen Psychiatry 1985;42:259-264.
ABSTRACT
Exaggerated Hyperprolactinemia in Response to Thiothixene
Ash and Bouma
Arch Neurol 1981;38:534-535.
ABSTRACT
Motility, Parkinsonism, and Prolactin With Thiothixene and Thioridazine
Crowley and Hydinger-Macdonald
Arch Gen Psychiatry 1981;38:668-675.
ABSTRACT
Serum Haloperidol Determinations in Psychiatric Patients: Comparison of Methods and Correlation With Serum Prolactin Level
Rubin et al.
Arch Gen Psychiatry 1980;37:1069-1074.
ABSTRACT
Side Effects Associated With Lithium Therapy
Reisberg and Gershon
Arch Gen Psychiatry 1979;36:879-887.
ABSTRACT
TRH (Protirelin) in Depressed Alcoholic Men: Behavioral Changes and Endocrine Responses
Loosen et al.
Arch Gen Psychiatry 1979;36:540-547.
ABSTRACT
Neuroleptic-induced Prolactin Level Elevation and Breast Cancer: An Emerging Clinical Issue
Schyve et al.
Arch Gen Psychiatry 1978;35:1291-1301.
ABSTRACT
Relation of Plasma Prolactin to Clinical Response in Schizophrenic Patients
Gruen et al.
Arch Gen Psychiatry 1978;35:1222-1227.
ABSTRACT
|
