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Clinical Evaluation of Naltrexone Treatment of Opiate-Dependent IndividualsReport of the National Research Council Committee on Clinical Evaluation of Narcotic Antagonists
Arch Gen Psychiatry. 1978;35(3):335-340.
Abstract
• A multiclinic controlled trial of naltrexone in opiate-dependent persons led to these conclusions: (1) a narcotic antagonist is an acceptable treatment for a small number of patients undergoing treatment for opiate dependence; (2) the group most likely to be candidates for such treatment are those who are relatively opiate-free ("post-addicts") and well motivated to seek treatment; (3) although differences between patients treated with placebo and naltrexone were slight, both retention in treatment and opiate-free urine tests favored the naltrexone group; (4) adverse effects of relatively short-term treatment were slight, largely being symptoms and signs of precipitated abstinence in patients with residual dependence.
Footnotes
Accepted for publication Aug 10, 1977.
For a list of committee members see p 340.
Reprint requests to Veterans Administration Hospital, 3801 Miranda Ave, Palo Alto, CA 94304 (Dr Hollister).
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