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An 18-Month Open Multicentric Study

Pierre Simon, MD; Jacques Fermanian, MD; Daniel Ginestet, MD; Michèle-Annie Goujet, MD; Pierre Péron-Magnan, MD

Arch Gen Psychiatry. 1978;35(7):893-897.

Abstract
• The overall objective of this 18-month open study was to compare standard neuroleptics and long-acting depot neuroleptics following the current psychiatric practice in order to determine the best therapy. Thirty French psychiatrists from 15 different wards participated in this experiment. One hundred eighty-one chronic schizophrenic patients were randomly assigned to receive one of the following three treatments: standard neuroleptics, pipotiazine palmitate, or fluphenazine decanoate. Criteria used for evaluation were an overall clinical evaluation by a psychiatrist, a Brief Psychiatric Rating Scale, and a Nurse's Observation Scale for Inpatient Evaluation. No significant difference (P >.05) was observed between the three groups in drug effectiveness or tolerance.

Author Affiliations
From the Department of Clinical Pharmacology, Faculté de Médecine Pitié-Salpére, Paris.

Footnotes
Accepted for publication Nov 1, 1977.

Reprint requests to Department of Clinical Pharmacology, Faculté de Médecine, Pitié-Salpétrière 91, Boulevard de l'Hôpital, 75634 Paris Cedex 13, France (Dr Simon).

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ABSTRACT