This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Association With Critical Developmental Disorders

Barbara Fish, MD; Wilfrid J. Dixon, PhD

Arch Gen Psychiatry. 1978;35(8):963-971.

Abstract
• Vestibular responses to caloric stimulation were measured from birth to age 2 years in ten infants born to schizophrenic mothers. This is part of a study of evolving neurointegrative disorders that may be associated with a genetic risk for schizophrenia. Transiently decreased vestibular responses coincided with several developmental disorders that were related to psychopathology at 10 years. Absent to decreased responses were associated with (1) a "pandevelopmental retardation" involving physical growth as well as postural-motor and visualmotor development, (2) an "abnormally quiet" state in the first month, and (3) failures of bimanual integration between 4 and 6 months. The transitory nature of the decreased nystagmus rules out the possibility of an organic lesion of the vestibular system. Rather, it suggests that some covert decrease in arousal accompanied those periods when central nervous system integration was disrupted.

Author Affiliations
From the Division of Child Psychiatry and Mental Retardation, Department of Psychiatry, and the Mental Retardation Research Center (Dr Fish), and the Department of Biomathematics and the Health Sciences Computing Facility (Dr Dixon), University of California at Los Angeles.

Footnotes
Accepted for publication July 19, 1976.

Reprint requests to Neuropsychiatric Institute, University of California at Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 (Dr Fish).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Neurobehavioral Deficits at Adolescence in Children at Risk for Schizophrenia: The Jerusalem Infant Development Study
Hans et al.
Arch Gen Psychiatry 1999;56:741-748.
ABSTRACT | FULL TEXT  

Children at Risk for Schizophrenia: The Jerusalem Infant Development Study: II. Neurobehavioral Deficits at School Age
Marcus et al.
Arch Gen Psychiatry 1993;50:797-809.
ABSTRACT  

Infants at Risk for Schizophrenia: Sequelae of a Genetic Neurointegrative Defect: A Review and Replication Analysis of Pandysmaturation in the Jerusalem Infant Development Study
Fish et al.
Arch Gen Psychiatry 1992;49:221-235.
ABSTRACT  

Vestibular Stimulation in Early Childhood: A Review
Sandler and Coren
Journal of Early Intervention 1981;3:48-55.
ABSTRACT  

Peripheral Vestibular Pathology in Schizophrenic Infants-Reply
Fish and Dixon
Arch Gen Psychiatry 1979;36:1463-1463.
ABSTRACT