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Paul M. Packman, MD; David A. Meyer, MD; Ronald M. Verdun

Arch Gen Psychiatry. 1978;35(9):1137-1141.

Abstract
• We describe prolonged apnea following electrotherapy in a patient who was also being treated with a topical organophosphate anticholinesterase, ecothiophate iodide (phospholine iodide), for glaucoma. The increased duration of action of succinylcholine resulted from low levels of serum cholinesterase that had been caused by the organophosphate. Attention is called to other drugs that directly or indirectly (by lowering serum cholinesterase) interact with succinylcholine chloride resulting in prolonged apnea. Other potential hazards of succinylcholine administration, such as hyperkalemia and cardiac arrhythmias, are also discussed.

Author Affiliations
From the Department of Psychiatry, Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication Aug 31, 1977.

Reprint requests to Department of Psychiatry, Washington University, Barnes and Renard Hospitals, 4940 Audubon Ave, St Louis, MO 63110 (Dr Packman).

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