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Platelet MAO Activity as a Case Study

Monte S. Buchsbaum, MD; Ronald O. Rieder, MD

Arch Gen Psychiatry. 1979;36(11):1163-1169.

Abstract
• This article examines current research strategies in biological psychiatry and the possible effects of biological heterogeneity on these strategies. First, the limited power of t test comparisons of measurements obtained from groups of patients and controls is demonstrated through a computer simulation. Second, we examine statistically the data from 14 recent platelet MAO studies to see if the heterogeneity in results of these studies could relate to an underlying biological heterogeneity. Finally, we suggest research methods we believe may be more useful than the current standard paradigm for elucidating the biological etiologies of psychiatric syndromes.

Author Affiliations
From the Biological Psychiatry Branch (Dr Buchsbaum) and the Laboratory of Psychology and Psychopathology (Dr Rieder), National Institute of Mental Health, Bethesda, Md.

Footnotes
Accepted for publication July 23, 1979.

Reprint requests to Bldg 10, Room 2N212, National Institute of Mental Health, Bethesda, MD 20014 (Dr Buchsbaum).

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