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Report of a New Pedigree Series

Elliot S. Gershon, MD; Steven D. Targum, MD; Steven Matthysse, PhD; William E. Bunney, Jr, MD

Arch Gen Psychiatry. 1979;36(13):1423-1430.

Abstract
• A new pedigree series of bipolar manic-depressive patients admitted to the National Institute of Mental Health intramural research program was evaluated for linkage between bipolar illness and red-green color blindness, since previous studies had indicated that close linkage was generally present. Using family study methods, six informative pedigrees were investigated. Analysis was performed using a multigenerational procedure and taking into account variable penetrance. Close linkage could be definitively ruled out as a general finding. Bipolar and related illnesses are thus not generally transmitted by a single major gene close to the protan/deutan region of the human X-chromosome.

Author Affiliations
From the Section on Psychogenetics, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md (Drs Gershon, Targum, and Bunney), and the Mailman Research Laboratories, McLean Hospital, Harvard Medical School, Belmont, Mass (Dr Matthysse).

Footnotes
Accepted for publication Dec 26, 1978.

Reprint requests to Section on Psychogenetics, Biological Psychiatry Branch, National Institute of Mental Health, 9000 Rockville Pike, Bldg 10, Rm 3N218, Bethesda, MD 20205 (Dr Gershon).

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