Monoamine Oxidase Inhibitors: A Review of Antidepressant Effectiveness

doi:10.1001/archpsyc.1979.01780070027003

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Vol. 36 No. 7, July 1979

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Monoamine Oxidase Inhibitors

A Review of Antidepressant Effectiveness

Frederic Quitkin, MD; Arthur Rifkin, MD; Donald F. Klein, MD

Arch Gen Psychiatry. 1979;36(7):749-760.

Abstract

• Data from double-blind, placebo-controlled trials ofthe monoamine oxidase (MAO) inhibitors show that phenelzineis clearly effective in neurotic or atypical depressives, butthe findings concerning its effect in endogenous depressivesare inconclusive. Although few controlled studies have beendone with tranylcypromine, similar conclusions are warranted.Studies have contrasted MAO inhibitors and tricyclic antidepressants(TCAs) to gain further information about the type of patientslikely to respond to MAO inhibitors. We believe that simplycontrasting the relative efficacy of TCAs and MAO inhibitorsis outdated. Neurotic or atypical depression is probably a heterogeneoussyndrome, and delineation of subtypes responsive to specificantidepressants is needed. The implications of fast acetylation,selective MAO inhibitors, types MAOA and MAOB5 and measuresof platelet MAO inhibition are discussed in this article.

Author Affiliations

From the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, and the New York State Psychiatric Institute, New York.

Footnotes

Accepted for publication Aug 17, 1978.

Reprint requests to New York State Psychiatric Institute, 722W 168th St, New York, NY 10032 (Dr Quitkin).

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