This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Morbidity Risk in Families of Patients With and Without Mitral Valve Prolapse

Raymond R. Crowe, MD; David L. Pauls, PhD; Donald J. Slymen, MS; Russell Noyes, MD

Arch Gen Psychiatry. 1980;37(1):77-79.

Abstract
• It has been suggested that some patients with anxiety neurosis (panic disorder) may have the mitral valve prolapse syndrome (MVPS) that can produce symptoms frequently associated with panic attacks. Previous work on a group of 21 patients with anxiety neurosis supported this hypothesis by finding MVPS in eight patients. These patients provided a unique opportunity to study the families of anxiety neurosis patients with and without MVPS to learn whether the high familial morbidity risk in anxiety neurosis is related to the presence or absence of MVPS in the proband. We interviewed first-degree relatives in 19 kindreds with anxiety neurosis and 19 control kindreds finding a morbidity risk for panic disorder of 41% among interviewed relatives and 31% based on data from all sources. These risks were substantially higher than those found among the control relatives. Seven kindreds were indexed through panic disorder probands with MVPS and when their kindreds were compared with those of the 12 panic disorder probands without MVPS, the familial morbidity risk for anxiety neurosis was similar. The data indicate that the familial morbidity risk for panic disorder is as high as any in the psychiatric genetics literature. However, it is independent of a diagnosis of MVPS in the proband.

Author Affiliations
From the Department of Psychiatry, University of Iowa College of Medicine, Iowa City.

Footnotes
Accepted for publication July 24, 1979.

Reprint requests to Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Rd, Iowa City, IA 52242 (Dr Crowe).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sympathetic Activity in Patients With Panic Disorder at Rest, Under Laboratory Mental Stress, and During Panic Attacks
Wilkinson et al.
Arch Gen Psychiatry 1998;55:511-520.
ABSTRACT | FULL TEXT  

Can Physicians Use Family Genogram Information to Identify Patients at Risk of Anxiety or Depression?
Rogers
Arch Fam Med 1994;3:1093-1098.
ABSTRACT  

Psychiatric Correlates of Behavioral Inhibition in Young Children of Parents With and Without Psychiatric Disorders
Biederman et al.
Arch Gen Psychiatry 1990;47:21-26.
ABSTRACT  

Behavioral Inhibition in Children of Parents With Panic Disorder and Agoraphobia: A Controlled Study
Rosenbaum et al.
Arch Gen Psychiatry 1988;45:463-470.
ABSTRACT  

Agoraphobia With Panic Attacks: Development, Diagnostic Stability, and Course of Illness
Breier et al.
Arch Gen Psychiatry 1986;43:1029-1036.
ABSTRACT  

Family-Genetic Studies of Psychiatric Disorders: Developing Technologies
Weissman et al.
Arch Gen Psychiatry 1986;43:1104-1116.
ABSTRACT  

Relationship Between Panic Disorder and Agoraphobia: A Family Study
Noyes et al.
Arch Gen Psychiatry 1986;43:227-232.
ABSTRACT  

Adrenergic Function in Patients With Panic Anxiety
Nesse et al.
Arch Gen Psychiatry 1984;41:771-776.
ABSTRACT  

Panic Disorder and Major Depression: Increased Risk of Depression, Alcoholism, Panic, and Phobic Disorders in Families of Depressed Probands With Panic Disorder
Leckman et al.
Arch Gen Psychiatry 1983;40:1055-1060.
ABSTRACT  

Family Study of Agoraphobia: Report of a Pilot Study
Harris et al.
Arch Gen Psychiatry 1983;40:1061-1064.
ABSTRACT  

A Family Study of Panic Disorder
Crowe et al.
Arch Gen Psychiatry 1983;40:1065-1069.
ABSTRACT  

Genetic Factors in Anxiety Disorders
Torgersen
Arch Gen Psychiatry 1983;40:1085-1089.
ABSTRACT  

Treatment of Agoraphobia and Panic Attacks
Matuzas and Glass
Arch Gen Psychiatry 1983;40:220-222.
ABSTRACT