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Their Relationships in Schizophrenic Patients

Göran C. Sedvall, MD; Birgitta Wode-Helgodt, MD

Arch Gen Psychiatry. 1980;37(10):1113-1116.

Abstract
• In 36 drug-free schizophrenic patients, lumbar CSF was analyzed by mass fragmentography for the major monoaminergic transmitter metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG). High or deviant concentrations of 5-HIAA were significantly related to a family history of schizophrenia. For patients with deviant 5-HIAA levels, the probability for a family history of schizophrenia was eight times higher than in subjects with normal values. High concentrations of HVA also tended to be significantly related to a family history of schizophrenia. The majority of schizophrenic patients, who lacked family history for the disorder, had normal monoamine metabolite concentrations in CSF. The results suggest a coupling between biochemical variables related to central serotonin and dopamine metabolism and forms of schizophrenia that have a familial disposition.

Author Affiliations
From the Laboratory of Experimental Psychiatry, Department of Psychiatry, Karolinska Hospital, Stockholm (Dr Sedvall); and the Department of Psychiatry, St Göran's Hospital, Karolinska Institute, Stockholm (Dr Wode-Helgodt).

Footnotes
Accepted for publication June 9, 1980.

Reprint requests to Laboratory of Experimental Psychiatry, Department of Psychiatry, Karolinska Hospital, S-104 01 Stockholm 60, Sweden (Dr Sedvall).

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