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II. Psychopathology, Tricyclic Concentration in Plasma, and Antienuretic Effect

Judith L. Rapoport, MD; Edwin J. Mikkelsen, MD; Anthony Zavadil, MD; Linda Nee, MSW; Cynthia Gruenau; Wallace Mendelson, MD; J. Christian Gillin, MD

Arch Gen Psychiatry. 1980;37(10):1146-1152.

Abstract
• The efficacy of treatment with imipramine hydrochloride, desipramine hydrochloride, methscopolamine bromide, and placebo was compared in a study with 40 severely enuretic boys. Both tricyclic antidepressants were superior to placebo and methscopolamine, but they did not differ from each other. Psychiatric disturbance, sleep measures, and other clinical parameters did not predict antienuretic response to tricyclics nor was there a psychotropic response. Plasma concentrations of imipramine and desipramine showed a significant correlation with clinical effect. However, true nonresponders were found, and tolerance to the antienuretic drugs developed in some boys.

Author Affiliations
From the Biological Psychiatry Branch (Drs Rapoport, Mikkelsen, Mendelson, and Gillin and Ms Gruenau) and the Laboratory of Clinical Science (Dr Zavadil and Ms Nee), National Institute of Mental Health, Bethesda, Md; and the Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, St Elizabeth's Hospital, Washington, DC (Drs Mendelson and Gillin).

Footnotes
Accepted for publication March 30, 1979.

Reprint requests to Unit on Childhood Mental Illness, Bldg 10, Room 3N-204, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20014 (Dr Rapoport).

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