Childhood enuresis. II. Psychopathology, tricyclic concentration in plasma, and antienuretic effect
J. L. Rapoport, E. J. Mikkelsen, A. Zavadil, L. Nee, C. Gruenau, W. Mendelson and J. C. Gillin
The efficacy of treatment with imipramine hydrochloride, desipramine
hydrochloride, methscopolamine bromide, and placebo was compared in a study
with 40 severely enuretic boys. Both tricyclic antidepressants were
superior to placebo and methscopolamine, but they did not differ from each
other. Psychiatric disturbance, sleep measures, and other clinical
parameters did not predict antienuretic response to tricyclics nor was
there a psychotropic response. Plasma concentrations of imipramine and
desipramine showed a significant correlation with clinical effect. However,
true nonresponders were found, and tolerance to the antienuretic drugs
developed in some boys.
