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Clomipramine and Doxepin in Depressive NeurosisPlasma Levels and Therapeutic Response
Markku Linnoila, MD, PhD;
Timo Seppala, MD;
Mauri J. Mattila, MD;
Reijo Vihko, MD;
Arto Pakarinen, MD;
J. Travis Skinner III, MSc
Arch Gen Psychiatry. 1980;37(11):1295-1299.
Abstract
• The therapeutic efficacy, plasma levels, and psychomotor effects of tryptophan (L-tryptophan), clomipramine hydrochloride, and doxepin were investigated in "neurotically" depressed outpatients. The tricyclic antidepressants were significantly more efficacious than tryptophan in inducing remission. The alleviation of depression was preceded by an improvement of the initially slow information-processing rates in the depressed patients. The plasma levels of the tricyclics that were associated with a therapeutic response were significantly lower than those reported in "endogenously" depressed inpatients.
Author Affiliations
From the Departments of Psychiatry and Pharmacology, Duke University Medical Center, Durham, NC (Dr Linnoila and Mr Skinner); the Department of Pharmacology, University of Helsinki, (Drs Linnoila, Seppala, and Mattila); and the Department of Clinical Chemistry, University of Oulu, Oulu, Finland (Drs Vihko and Pakarinen).
Footnotes
Accepted for publication Dec 10, 1979.
Reprint requests to Box 2921, Duke University Medical Center, Durham, NC 27710 (Dr Linnoila).
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