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Relationship With Platelet and Plasma MAO Activities

Herbert Y. Meltzer, MD; Ramesh C. Arora, MD

Arch Gen Psychiatry. 1980;37(3):333-339.

Abstract
• The skeletal muscle MAO activity of schizophrenics and patients with bipolar and unipolar affective psychoses was lower than that of normal controls. Both platelet and plasma MAO actvity was significantly lower in the schizophrenics and patients with undiagnosed psychoses than in the normal controls. platelet and plasma MAO activities were not correlated with skeletal muscle MAO activity. Both human platelet and skeletal muscle MAO are type B MAO and have similar kinetic constants. The decrease in skeletal muscle MAO activity in various types of psychotic patients is consistent with previous suggestions based on platelet studies that low MAO activity may be a nonspecific factor contributing to the development of different forms of psychopathology. Since total skeletal muscle MAO activity is the largest source of MAO in the body, it is possible that the decrease in muscle MAO activity may lead to excessive quantities of biogenic amines that could adversely affect neural activity.

Author Affiliations
From the Department of Psychiatry, University of Chicago Pritzker School of Medicine, and the Illinois State Psychiatric Institute, Chicago.

Footnotes
Accepted for publication Sept 27, 1979.

Reprint requests to Department of Psychiatry, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr Meltzer).

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