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Intravenous Infusion Causes Behavioral Change in Psychiatric Inpatients

Robert H. Gerner, MD; Don H. Catlin, MD; David A. Gorelick, PhD, MD; Ka Kit Hui, MD; Cho Hao Li, PhD

Arch Gen Psychiatry. 1980;37(6):642-647.

Abstract
• Ten depressed and eight schizophrenic patients received synthetic human β-endorphin infusions in a double-blind, placebo-controlled, crossover design. Physicians' and nurses' ratings and patients' self-ratings were used to measure behavioral change. Depressed patients improved significantly two to four hours after β-endorphin treatment when compared with placebo treatment. There was no significant change in the schizophrenic patients as a group, although six of eight worsened after β-endorphin treatment. No significant behavioral effects were observed during the infusions themselves or on postinfusion days.

Author Affiliations
From the Department of Psychiatry, Neuropsychiatric Institute (Dr Gerner), the Departments of Medicine and Pharmacology (Drs Catlin and Hui), and the Departments of Psychiatry and Pharmacology (Dr Gorelick), Center for the Health Sciences, University of California, Los Angeles; and the Hormone Research Laboratory, University of California, San Francisco (Dr Li).

Footnotes
Accepted for publication Feb 8, 1980.

Reprint requests to UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024 (Dr Gerner).

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