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Lil Träskman; Gunnel Tybring; Marie Åsberg, MD; Leif Bertilsson, PhD; Olle Lantto, MSci; Daisy Schalling, PhD

Arch Gen Psychiatry. 1980;37(7):761-767.

Abstract
• Cortisol concentrations in CSF were measured by radioimmunoassay in healthy controls, depressed patients, patients who had attempted suicide but were not depressed, and obsessivecompulsive patients. The factors that contributed most to the variance in CSF cortisol levels were a diagnosis of depression, height, and important life changes during the six months preceding the investigation. Depression was by far the most important factor. The depressed patients had significantly higher CSF cortisol levels than the controls. In obsessive-compulsive and depressed patients treated with clomipramine hydrochloride, the levels were significantly reduced. Cortisol levels in CSF were significantly correlated with mean urinary cortisol excretion. Of the three monoamine metabolites measured, only 5-hydroxyindoleacetic acid level was weakly correlated with CSF cortisol level. This correlation was confined to the depressed patients and could be accounted for by the common correlation with height.

Author Affiliations
From the Department of Psychiatry, Karolinska Hospital (Drs Träskman and Åsberg); the Departments of Clinical Pharmacology (Mr Tybring and Dr Bertilsson) and Clinical Chemistry (Mr Lantto), Huddinge Hospital, Karolinska Institute; and the Department of Psychology, University of Stockholm (Dr Schalling), Stockholm.

Footnotes
Accepted for publication Jan 15, 1980.

Reprint requests to Psychiatric Clinic, Karolinska Hospital, S-104 01 Stockholm 60, Sweden (Dr Träskman).

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