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Their Role as Predictors of Differential Response to Psychotherapy and Drug Treatment

Brigitte A. Prusoff, PhD; Myrna M. Weissman, PhD; Gerald L. Klerman, MD; Bruce J. Rounsaville, MD

Arch Gen Psychiatry. 1980;37(7):796-801.

Abstract
• We studied the usefulness of the research diagnostic criteria subtypes in the prediction of response to amitriptyline and short-term interpersonal psychotherapy (IPT) in a 16-week, controlled, randomized clinical trial with 81 ambulatory depressed patients. Both patients with a situational depression and patients with an endogenous depression responded to combined treatment; those with an endogenous depression did not respond to IPT alone, whereas those with a situational depression responded to IPT or tricyclic medication alone. It may not be necessary to offer both treatments to the situationally depressed patients. However, situational and endogenous are not mutually exclusive diagnoses, and it would be of clinical interest to obtain a longer group of patients with both diagnoses for further study.

Author Affiliations
From the Department of Psychiatry, Yale University School of Medicine and the Depression Research Unit, Connecticut Mental Health Center (Drs Prusoff, Weissman, and Rounsaville), New Haven, Conn, and the Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston (Dr Klerman).

Footnotes
Accepted for publication Dec 10, 1979.

Reprint requests to Depression Research Unit, Connecticut Mental Health Center, 904 Howard Ave, Suite 2A, New Haven, CT 06519. (Dr Prusoff).

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