This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (374)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Clinical Genetics, Natural History, and Associated Conditions

Leonard L. Heston, MD; Angeline R. Mastri, MD; V. Elving Anderson, PhD; June White

Arch Gen Psychiatry. 1981;38(10):1085-1090.

Abstract
• Relatives of 125 probands, who had dementia of the Alzheimer type as proved by autopsy, were subjects of a genetic investigation. The relatives exhibited an excess of dementing illness consistent with genetic transmission. Risk to relatives decreased sharply as severity of the proband's illness decreased. Also, when compared with a control group and the general population, the relatives had excesses of Down's syndrome, lymphoma, and immune diatheses. These associated conditions also were more likely to be present when the proband had severe illness. Mortality at all ages was increased among the relatives.

Author Affiliations
From the Department of Psychiatry, Psychiatry Research Unit (Dr Heston and Ms White); the Division of Neuropathology, Department of Laboratory Medicine and Pathology (Dr Mastri); and the Dight Institute for Human Genetics (Dr Anderson), University of Minnesota, Minneapolis.

Footnotes
Accepted for publication April 6, 1981.

Reprint requests to Department of Psychiatry, Psychiatry Research Unit, Box 392 Mayo, University of Minnesota, Minneapolis, MN 55455 (Dr Heston).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Mosaicism for Trisomy 21 in a Patient With Young-Onset Dementia: A Case Report and Brief Literature Review
Ringman et al.
Arch Neurol 2008;65:412-415.
ABSTRACT | FULL TEXT  

Glucose metabolism in early onset versus late onset Alzheimer's disease: an SPM analysis of 120 patients
Kim et al.
Brain 2005;128:1790-1801.
ABSTRACT | FULL TEXT  

Prevalence of dementia in an urban population in Kerala, India
SHAJI et al.
Br. J. Psychiatry 2005;186:136-140.
ABSTRACT | FULL TEXT  

Essentials of the Proper Diagnoses of Mild Cognitive Impairment, Dementia, and Major Subtypes of Dementia
Knopman et al.
Mayo Clin Proc. 2003;78:1290-1308.
ABSTRACT  

Specificity of the fivefold increase in AD in mothers of adults with Down syndrome
Schupf et al.
Neurology 2001;57:979-984.
ABSTRACT | FULL TEXT  

A Family Study of Alzheimer Disease and Early- and Late-Onset Depression in Elderly Patients
Heun et al.
Arch Gen Psychiatry 2001;58:190-196.
ABSTRACT | FULL TEXT  

Genetic risk of Alzheimer's disease: advising relatives
LIDDELL et al.
Br. J. Psychiatry 2001;178:7-11.
ABSTRACT | FULL TEXT  

Prospective Study of Risk Factors for Alzheimer's Disease: Results at 7.5 Years
Zubenko et al.
Am. J. Psychiatry 1999;156:50-57.
ABSTRACT | FULL TEXT  

Wide Range of Disease Onset in a Family With Alzheimer Disease and a His163Tyr Mutation in the Presenilin-1 Gene
Axelman et al.
Arch Neurol 1998;55:698-702.
ABSTRACT | FULL TEXT  

The Validity of the Family History Method for Identifying Alzheimer Disease
Li et al.
Arch Neurol 1997;54:634-640.
ABSTRACT  

The Role of Heredity in Late-Onset Alzheimer Disease and Vascular Dementia: A Twin Study
Bergem et al.
Arch Gen Psychiatry 1997;54:264-270.
ABSTRACT  

A Large Swedish Family With Alzheimer's Disease With a Codon 670/671 Amyloid Precursor Protein Mutation: A Clinical and Genealogical Investigation
Axelman et al.
Arch Neurol 1994;51:1193-1197.
ABSTRACT  

Factors Affecting Course and Survival in Alzheimer's Disease: A 9-Year Longitudinal Study
Bracco et al.
Arch Neurol 1994;51:1213-1219.
ABSTRACT  

Extrapyramidal Signs and Psychiatric Symptoms Predict Faster Cognitive Decline in Alzheimer's Disease
Chui et al.
Arch Neurol 1994;51:676-681.
ABSTRACT  

The Natural History of Alzheimer's Disease: Description of Study Cohort and Accuracy of Diagnosis
Becker et al.
Arch Neurol 1994;51:585-594.
ABSTRACT  

Evidence of Subtypes of Alzheimer's Disease and Implications for Etiology
Bondareff et al.
Arch Gen Psychiatry 1993;50:350-356.
ABSTRACT  

Clinical Genetics and Genetic Counseling in Alzheimer Disease
Breitner
ANN INTERN MED 1991;115:601-606.
ABSTRACT  

Magnetic Resonance Imaging Hyperintensities in Alzheimer's Disease
McDonald et al.
Arch Neurol 1991;48:468-468.
ABSTRACT  

The Prognosis in Alzheimer's Disease: 'How Far' Rather Than 'How Fast' Best Predicts the Course
Drachman et al.
Arch Neurol 1990;47:851-856.
ABSTRACT  

Alzheimer's Disease: Age at Onset and Single-Photon Emission Computed Tomographic Patterns of Regional Cerebral Blood Flow
Jagust et al.
Arch Neurol 1990;47:628-633.
ABSTRACT  

Dementia: A Review Emphasizing Clinicopathologic Correlation and Brain-Behavior Relationships
Chui
Arch Neurol 1989;46:806-814.
ABSTRACT  

Age related patterns of decline in dementia as measured by the hierarchic dementia scale (HDS)
Dastoor and Cole
AM J ALZHEIMERS DIS OTHER DEMEN 1988;3:29-35.
 

Alois Alzheimer on Presenile Dementia
Tonkonogy and Moak
J Geriatr Psychiatry Neurol 1988;1:199-206.
ABSTRACT  

Familial Risk of Dementia Associated With a Biologic Subtype of Alzheimer's Disease
Zubenko et al.
Arch Gen Psychiatry 1988;45:889-893.
ABSTRACT  

A Family-Genetic Study of Dementia of Alzheimer Type
Martin et al.
Arch Gen Psychiatry 1988;45:894-900.
ABSTRACT  

Biologic Markers, Genetics, and Alzheimer's Disease
Small and Greenberg
Arch Gen Psychiatry 1988;45:945-947.
ABSTRACT  

Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease
Schellenberg et al.
Science 1988;241:1507-1510.
ABSTRACT  

Electroencephalographic Correlates of Increased Platelet Membrane Fluidity in Alzheimer's Disease
Zubenko et al.
Arch Neurol 1988;45:1009-1013.
ABSTRACT  

Alzheimer Disease: Clinical and Biological Heterogeneity
Friedland et al.
ANN INTERN MED 1988;109:298-311.
ABSTRACT  

Research in Alzheimer's disease: A progress report
Moss
AM J ALZHEIMERS DIS OTHER DEMEN 1988;3:10-16.
 

Morbid Risk in First-Degree Relatives of Persons With Alzheimer's Disease
Heston
Arch Gen Psychiatry 1988;45:97-98.
ABSTRACT  

Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease
St George-Hyslop et al.
Science 1987;238:664-666.
ABSTRACT  

Family study of platelet membrane fluidity in Alzheimer's disease
Zubenko et al.
Science 1987;238:539-542.
ABSTRACT  

Age at Onset in Schizophrenia: A Familial Perspective
Kendler et al.
Arch Gen Psychiatry 1987;44:881-890.
ABSTRACT  

Using Molecular Probes In The Study Of Alzheimer's Disease
Sinex
AM J ALZHEIMERS DIS OTHER DEMEN 1987;2:5-8.
 

Alzheimer's Disease: Morbid Risk Among First-Degree Relatives Approximates 50% by 90 Years of Age
Mohs et al.
Arch Gen Psychiatry 1987;44:405-408.
ABSTRACT  

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
Tanzi et al.
Science 1987;235:880-884.
ABSTRACT  

The genetic defect causing familial Alzheimer's disease maps on chromosome 21
St George-Hyslop et al.
Science 1987;235:885-890.
ABSTRACT  

Risk of Alzheimer's Disease for First Degree Relatives
Sinex
AM J ALZHEIMERS DIS OTHER DEMEN 1986;1:14-17.
 

Neocortical Metabolic Abnormalities Precede Nonmemory Cognitive Defects in Early Alzheimer's-Type Dementia
Haxby et al.
Arch Neurol 1986;43:882-885.
ABSTRACT  

Fingerprint Pattern Differences in Early- and Late-Onset Primary Degenerative Dementia
Seltzer and Sherwin
Arch Neurol 1986;43:665-668.
ABSTRACT  

Etiologic theories of Alzheimer's disease
Schweber
AM J ALZHEIMERS DIS OTHER DEMEN 1986;1:24-31.
ABSTRACT  

Alzheimer's Disease and Down's Syndrome: New Insights
CUTLER et al.
ANN INTERN MED 1985;103:566-578.
ABSTRACT  

Fingerprint Patterns in Alzheimer's Disease
Weinreb
Arch Neurol 1985;42:50-54.
ABSTRACT  

Alzheimer's disease: a disorder of cortical cholinergic innervation
Coyle et al.
Science 1983;219:1184-1190.
ABSTRACT