This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Walter A. Brown, MD; Thomas P. Laughren, MD; Bradford Williams

Arch Gen Psychiatry. 1981;38(11):1270-1272.

Abstract
• Previous studies showing inconsistent effects of neuroleptic agents on the pituitary-gonadal system suggest that the drugs may differ in their effects on this system. Serum testosterone, luteinizing hormone (LH), prolactin, and neuroleptic levels were measured in 42 male schizophrenic patients during long-term treatment with thioridazine hydrochloride, trifluoperazine hydrochloride, chlorpromazine hydrochloride, and other neuroleptic agents and in six drug-free patients. Serum testosterone and LH values were significantly lower in patients taking thioridazine than in those taking other neuroleptic drugs. The relatively high serum neuroleptic levels in patients taking thioridazine may account for its differential effect on the pituitary-gonadal system.

Author Affiliations
From the Veterans Administration Medical Center (Drs Brown and Laughren and Mr Williams) and Brown University (Drs Brown and Laughren), Providence, RI.

Footnotes
Accepted for publication June 15, 1981.

Reprint requests to Veterans Administration Medical Center, Davis Park, Providence, RI 02908 (Dr Brown).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?