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Platelet 2-Adrenergic Receptors in Major Depressive Disorder

Binding of Tritiated Clonidine Before and After Tricyclic Antidepressant Drug Treatment

Jesus A. García-Sevilla, MD; Athanasios P. Zis, MD; Peggie J. Hollingsworth, MA; John F. Greden, MD; Charles B. Smith, MD, PhD

Arch Gen Psychiatry. 1981;38(12):1327-1333.

Abstract
• The specific binding of tritiated (³H)-clonidine, an ₂-adrenergic receptor agonist, to platelet membranes was measured in normal subjects and in patients with major depressive disorder. The number of platelet ₂-adrenergic receptors from the depressed group was significantly higher than that found in platelets obtained from the control population. Treatment with tricyclic antidepressant drugs led to significant decreases in the number of platelet ₂-adrenergic receptors. These results support the hypotheses that the depressive syndrome is related to an ₂-adrenergic receptor supersensitivity and that the clinical effectiveness of tricyclic antidepressant drugs is associated with a decrease in the number of these receptors.

Author Affiliations
From the Departments of Pharmacology (Drs García-Sevilla and Smith and Ms Hollingsworth) and Psychiatry (Drs Zis and Greden), The University of Michigan Medical School, Ann Arbor.

Footnotes
Accepted for publication Aug 5, 1981.

Portions of this study were read before the annual meetings of the Federation of American Societies for Experimental Biology, Atlanta, April 13, 1981, and of the American Psychiatric Association, New Orleans, May 12, 1981.

Reprint requests to Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109 (Dr Smith).

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