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Effect of Des-Tyrosine- -Endorphin in Tardive Dyskinesia
Daniel E. Casey, MD;
Soren Korsgaard, MD;
Jes Gerlach, MD;
Aage Jørgensen, MD;
Hans Simmelsgaard, MD
Arch Gen Psychiatry. 1981;38(2):158-160.
Abstract
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• The endorphin neuropeptides may have neuroleptic-like effects on dopamine function and may be antischizophrenic. Ten chronic psychotic patients with neuroleptic-induced tardive dyskinesia and parkinsonism received placebo and des-tyrosine -endorphin (DTE). Drug effects on movement disorders and eye-blinking rates were assessed by blind evaluations of randomly sequenced videotapes made during standardized examinations before and 30, 60, and 120 minutes after each injection and at 24 hours postinjection on days of consecutive treatment. Changes in schizophrenic symptoms were evaluated openly with the schizophrenia subscale of the Comprehensive Psychiatric Rating Scale. There were no significant effects of DTE on any parameter and no side effects. This suggests that DTE, within the tested dose range, does not influence the pathophysiology of neuroleptic-induced dyskinesias or chronic schizophrenia or have neuroleptic properties. However, DTE is well tolerated and should be tested with higher doses during prolonged treatment.
Author Affiliations
From Departments H, E, and G, Sankt Hans Mental Hospital, Roskilde, Denmark (Drs Casey, Korsgaard, Gerlach, Jørgensen, and Simmelsgaard); and the Departments of Medical Research, Psychiatry, and Neurology, Veterans Administration Medical Center and University of Oregon Health Sciences Center, Portland (Dr Casey).
Footnotes
Accepted for publication Oct 22, 1980.
Reprint requests to Department of Psychiatry, VA Medical Center, 3710 SW US Veterans Hospital Rd, Portland, OR 97201 (Dr Casey).
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