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A Multicenter Collaborative Perspective

Nancy C. Andreasen, MD, PhD; William M. Grove, MA; Robert W. Shapiro, MD; Martin B. Keller, MD; Robert M. A. Hirschfeld, MD; Patricia McDonald-Scott, MA

Arch Gen Psychiatry. 1981;38(4):400-405.

Abstract
• It is important to determine the reliability of lifetime diagnosis in a nonpatient population, for this type of diagnostic data and this type of sample are used in many genetic, epidemiological, and nosological studies. We examined the reliability of lifetime diagnosis when the Schedule for Affective Disorders and Schizophrenia-Lifetime Version and Research Diagnostic Criteria were used to interview ill and well relatives of probands in the National Institute of Mental Health Collaborative Study of the Psychobiology of Depression. Subjects were interviewed three times, so data are available concerning both short- and longinterval test-retest reliability. Short-interval test-retest reliability was excellent for both diagnoses and symptoms. Reliability was also quite high in the long-interval test-retest study. We conclude that it is possible to make lifetime diagnoses reliably in a nonpatient population.

Author Affiliations
From the Department of Psychiatry, University of Iowa, Iowa City (Dr Andreasen and Mr Grove); the Department of Psychiatry, Harvard University, Cambridge, Mass (Drs Shapiro and Keller); the National Institute of Mental Health, Rockville, Md (Dr Hirschfeld); and New York State Psychiatric Institute, New York (Ms McDonald-Scott).

Footnotes
Accepted for publication Nov 13, 1980.

Deceased.

Reprint requests to Department of Psychiatry, University of Iowa, 500 Newton Rd, Iowa City, IA 52242 (Dr Andreasen).

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