 |
|
Blood Tryptophan Metabolism in Chronic Schizophrenics
Daniel X. Freedman, MD;
Krystyna Belendiuk, PhD;
George W. Belendiuk, MD, PhD;
John W. Crayton, MD
Arch Gen Psychiatry. 1981;38(6):655-659.
Abstract
| |
• Concomitant measures of blood indole metabolism were conducted in 33 chronic schizophrenics who showed significantly elevated mean platelet serotonin (5-HT) values and lower platelet monoamine oxidase (MAO) and plasma amine oxidase activities than normals. When subdivided according to Research Diagnostic Criteria diagnosis, the 20 chronic undifferentiated (CU) schizophrenics showed these same deviations from normal; the 13 chronic paranoid (CP) schizophrenics also had significantly higher mean 5-HT values but significantly lower plasma concentrations of total and bound tryptophan. In CP schizophrenics, platelet MAO activity, but not plasma amine oxidase activity, was significantly lower than in CU schizophrenics and controls. Hyperserotonemia occurred in 11 of the chronic patients (33%); nine were CU schizophrenics. In the latter, total tryptophan concentration was significantly lowered. Hyperserotonemia was not associated with reduced liver tryptophan pyrrolase activity or platelet MAO or plasma amine oxidase activities; rather, it may be a consequence of enhanced tissue tryptophan uptake and utilization.
Author Affiliations
From the Department of Psychiatry, University of Chicago. Dr G. W. Belendiuk is now with the Department of Neurology, University of Chicago.
Footnotes
Accepted for publication Dec 28, 1980.
Reprint requests to Department of Psychiatry, Box 411, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr Freedman).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Platelets and Psychiatry: Lessons Learned From Old and New Studies
Camacho and Dimsdale
Psychosom. Med. 2000;62:326-336.
ABSTRACT
| FULL TEXT
The psychopharmacology of autism and related disorders
Gillberg
J Psychopharmacol 1996;10:54-63.
m-Chlorophenylpiperazine Effects in Neuroleptic-Free Schizophrenic Patients: Evidence Implicating Serotonergic Systems in the Positive Symptoms of Schizophrenia
Krystal et al.
Arch Gen Psychiatry 1993;50:624-635.
ABSTRACT
Effects of Clozapine and Fluphenazine Treatment on Responses to m-Chlorophenylpiperazine Infusions in Schizophrenia
Owen et al.
Arch Gen Psychiatry 1993;50:636-644.
ABSTRACT
Biochemical Changes During Clomipramine Treatment of Childhood Obsessive-Compulsive Disorder
Flament et al.
Arch Gen Psychiatry 1987;44:219-225.
ABSTRACT
LSD and Schizophrenia
Weaver
Arch Gen Psychiatry 1984;41:631-631.
ABSTRACT
Social and Environmental Influences on Blood Serotonin Concentrations in Monkeys
Raleigh et al.
Arch Gen Psychiatry 1984;41:405-410.
ABSTRACT
Plasma Amine Oxidase and Genetic Vulnerability to Schizophrenia
Baron et al.
Arch Gen Psychiatry 1983;40:275-279.
ABSTRACT
|
