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The Jerusalem Infant Development Study

Joseph Marcus, MD; Judith Auerbach, PhD; Leland Wilkinson, PhD; Charles M. Burack

Arch Gen Psychiatry. 1981;38(6):703-713.

Abstract
• The development of infants born to parents with serious mental disorders was followed up from birth through the first year of life. An individual-differences approach to statistical analysis, Multidimensional Scalogram Analysis (MSA), was shown to be an effective statistical procedure for examining heterogeneous psychiatric populations. The MSA revealed the existence of a subgroup of infants born to schizophrenics who repeatedly performed poorly in motor and sensorimotor areas of functioning during their first year of life. These infants were especially vulnerable to external insults, and many had low to low-normal birth weights. These findings, taken together with similar findings from other investigations, add support to the hypothesis that these infants may have a genetically determined neurointegrative deficit.

Author Affiliations
From the Department of Psychiatry, University of Chicago (Drs Marcus and Auerbach and Mr Burack); and the Department of Psychology, University of Illinios Circle Campus, Chicago (Dr Wilkinson). Dr Marcus was Director of Child Psychiatry and Dr Auerbach was Research Associate at the Jerusalem Mental Health Center.

Footnotes
Accepted for publication July 24, 1980.

A preliminary report on many of the findings in this report was read before the Plenary Session of the Consortium of At-Risk Research in Schizophrenia, San Juan, Puerto Rico, March 11, 1980.

Reprint requests to Department of Psychiatry, Box 411, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr Marcus).

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