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I. The Relationship Between Anxiety Disorder and Schizophrenia

Kenneth S. Kendler, MD; Alan M. Gruenberg, MD; John S. Strauss, MD

Arch Gen Psychiatry. 1981;38(9):973-977.

Abstract
• Familial factors have been shown to be important in the transmission of both anxiety disorder and schizophrenia. The familial relationship between these two disorders, however, has received little attention. This study examines the relationship between anxiety disorder and schizophrenia by a blind independent analysis of the interviews from the Danish Adoption Study of Schizophrenia using DSM-Ill criteria. The results show neither a genetic nor a familial-environmental link between the two disorders. These results are not consistent with the unitary hypothesis of mental illness. From a genetic and familial-environmental perspective, anxiety disorder and schizophrenia appear to be distinct, unrelated psychiatric illnesses.

Author Affiliations
From the Department of Psychiatry and the Schizophrenia Biological Research Center, Bronx Veterans Administration Medical Center, Mt Sinai School of Medicine, Bronx, NY (Dr Kendler); the Connecticut Mental Health Center, New Haven (Dr Gruenberg); and the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn (Drs Gruenberg and Strauss).

Footnotes
Accepted for publication April 20, 1981.

An earlier version of this report was read before the meeting of the American Psychiatric Association, San Francisco, May 7, 1980.

Reprint requests to Department of Psychiatry, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468 (Dr Kendler).

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