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Demographic Characteristics, Clinical Features, and Family History

Ming T. Tsuang, MD, PhD, DSc; John C. Simpson, PhD; Ziad Kronfol, MD

Arch Gen Psychiatry. 1982;39(2):141-147.

Abstract
• Hospital records of 72 drug abusers with psychoses (DAP) were analyzed to clarify the relationship between drug abuse and psychosis. Comparison groups included schizophrenics and atypical schizophrenics without drug abuse and drug abusers without psychoses (DA). Compared with DAP in whom psychoses lasted less than six months before admission (DAP-short), drug abusers with psychoses of a longer duration (DAP-long) had more symptoms, more premorbid personality disorders, and greater familial risks of schizophrenia and affective disorder. The DAP-long group resembled atypical schizophrenia for clinical features and family history, whereas the DAP-short group resembled DA for some clinical features and family history. The results indicate that there are several subgroups of DAP. The importance of clinical features and family history in identifying subgroups of DAP was stressed.

Author Affiliations
From the Department of Psychiatry, University of Iowa College of Medicine, Iowa City (Drs Tsuang and Simpson), and the Department of Psychiatry, University of Michigan Medical Center, Ann Arbor (Dr Kronfol).

Footnotes
Accepted for publication May 1, 1981.

Read in part before the New Research Session of the 134th annual meeting of the American Psychiatric Association, New Orleans, May 14, 1981.

Reprint requests to Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Rd, Iowa City, IA 52242 (Dr Tsuang).

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