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Use in Normal Subjects and in Patients With Schizophrenia

Monte S. Buchsbaum, MD; David H. Ingvar, MD; Robert Kessler, MD; Robert N. Waters, MD; John Cappelletti; Daniël P. van Kammen, MD; A. Catherine King; Jeannette L. Johnson, MS; Ronald G. Manning, PhD; Richard W. Flynn, PhD; Lee S. Mann, MS; William E. Bunney, Jr, MD; Louis Sokoloff, MD

Arch Gen Psychiatry. 1982;39(3):251-259.

Abstract
• Local cerebral uptake of deoxyglucose labeled with fluorine 18 was measured by positron-emission tomography in eight patients with schizophrenia who were not receiving medication and in six age-matched normal volunteers. Subjects sat in an acoustically treated, darkened room with eyes closed after injection of 3 to 5 mCi of deoxyglucose ¹⁸F. After uptake, seven to eight horizontal brain scans parallel to the canthomeatal line were done. Scans were treated digitally, with a 2.3-cm strip peeled off each slice and ratios to whole-slice activity computed. Patients with schizophrenia showed lower ratios in the frontal cortex, indicating relatively lower glucose use than normal control subjects; this was consistent with previously reported studies of regional cerebral blood flow. Patients also showed diminished ratios for a 2.3-cm square that was positioned over central gray-matter areas on the left but not on the right side. These findings are preliminary; issues of control of mental activity, brain structure identification, and biologic and anatomic heterogeneity of schizophrenia remain to be explored.

Author Affiliations
From the Biological Psychiatry Branch (Drs Buchsbaum, Waters, van Kammen, and Bunney, Messrs Cappelletti and Mann, and Mss King and Johnson) and the Laboratory of Cerebral Metabolism (Dr Sokoloff and visiting scientist Dr Ingvar), National Institute of Mental Health, and the Department of Nuclear Medicine (Drs Kessler, Manning, and Flynn), National Institutes of Health Clinical Center, Bethesda, Md.

Footnotes
Accepted for publication Nov 17, 1981.

Reprint requests to Section on Clinical Psychophysiology, Biological Psychiatry Branch, National Institute of Mental Health Clinical Center, 2N212, Bethesda, MD 20205 (Dr Buchsbaum).

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