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A Study of Prevalence and Association With Demographic, Clinical, and Drug History Variables

Sukdeb Mukherjee, MD; Arnold M. Rosen, MD; Carlos Cardenas, MD; Virendra Varia, MD; Silvia Olarte, MD

Arch Gen Psychiatry. 1982;39(4):466-469.

Abstract
• We examined 153 psychiatric outpatients, on a maintenance regimen of neuroleptics, for tardive dyskinesia (TD) and parkinsonism. Demographic, clinical, and drug history data were collected to assess whether any of these factors were significantly associated with TD. After initial univariate screening, significant variables were analyzed by multivariate statistical methods. Tardive dyskinesia was significantly associated with the use of high-potency or high-dosage neuroleptics and depot fluphenazine, whereas low-potency neuroleptics were negatively correlated with moderate TD. Age, but not sex, correlated significantly with TD, as did histories of incoherence, grandiose delusions, and teeth or denture problems. Parkinsonism and TD were strongly associated. Although the prevalence of TD was quite high, there were no severe involvements of any of the Abnormal Involuntary Movement Scale body areas.

Author Affiliations
From the Psychopharmacology Program, Psychiatry Out Patient Department, Metropolitan Hospital Center, New York (Drs Mukherjee, Rosen, and Olarte), and the Department of Psychiatry, New York Medical College (Drs Mukherjee, Rosen, Cardenas, Varia, and Olarte).

Footnotes
Accepted for publication Oct 27, 1981.

Reprint requests to Psychopharmacology Program, Psychiatry Out Patient Department, Room 1M60, Metropolitan Hospital Center, 1900 Second Ave, New York, NY 10029 (Dr Mukherjee).

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