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A New Treatment for Patients With Refractory Rapid-Cycling Disorder

William Z. Potter, MD, PhD; Dennis L. Murphy, MD; Thomas A. Wehr, MD; Markku Linnoila, MD, PhD; Frederick K. Goodwin, MD

Arch Gen Psychiatry. 1982;39(5):505-510.

Abstract
• Five women with primary, major, bipolar affective disorder, characterized by rapid mood cycles and nonresponsiveness to conventional drug treatments, including lithium carbonate, were given low doses (2.5 to 10.0 mg/24 hr) of clorgyline, a selective inhibitor of monoamine oxidase type A. In four patients, clorgyline, alone or in combination with lithium carbonate, prolonged the duration and lessened the severity of mood cycles. One patient experienced prolonged manias while receiving clorgyline therapy. Clorgyline-induced remissions have lasted from three to more than 12 months.

Author Affiliations
From the Clinical Psychobiology (Drs Potter, Wehr, Linnoila, and Goodwin) and Clinical Neuropharmacology (Dr Murphy) Branches, National Institute of Mental Health, Bethesda, Md.

Footnotes
Accepted for publication Nov 5, 1981.

Reprint requests to Clinical Psychobiology Branch, National Institute of Mental Health, Room 4S239, Bldg 10, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Potter).

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