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Markku Linnoila, MD, PhD; Farouk Karoum, PhD; William Z. Potter, MD, PhD

Arch Gen Psychiatry. 1982;39(5):513-516.

Abstract
• Effects of clorgyline on urinary excretion of norepinephrine, dopamine, tyramine, and their major metabolites, 5-hydroxyindoleacetic acid and phenylethylamine, were studied in four women who suffered from primary, bipolar affective disorder. All patients had rapid mood cycles and were nonresponsive to lithium carbonate. During placebo administration, a strong correlation was found between the excretion rates of norepinephrine and dopamine and their respective metabolites. Clorgyline, 5 to 10 mg every or every other day, reduced overallbody norepinephrine turnover by 55% and increased tyramine but did not alter 5-hydroxyindoleacetic acid, phenylethylamine, or p-hydroxyphenylacetic acid excretion. These findings demonstrate the clinical actions of low-dose clorgyline and clorgyline's specificity as a monoamine oxidase A (MAO-A) inhibitor in vivo in humans, as well as the effects of specific MAO-A inhibition on monoamine metabolism.

Author Affiliations
From the Clinical Psychobiology (Drs Linnoila and Potter) and Adult Psychiatry (Dr Karoum) Branches, National Institute of Mental Health, Bethesda, Md.

Footnotes
Accepted for publication Nov 5, 1981.

Reprint requests to Clinical Psychobiology Branch, National Institute of Mental Health, Room 4S239, Bldg 10, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Linnoila).

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