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David J. Kupfer, MD; David H. Shaw, MS; Richard Ulrich, MS; Patricia A. Coble, RN; Duane G. Spiker, MD

Arch Gen Psychiatry. 1982;39(5):569-573.

Abstract
• Application of automated rapid-eye-movement (REM) analysis can characterize individual REM periods in depressed patients. Average REM count for the individual REM periods generally demonstrated considerable decreases in the second half of the REM period and differentiated patients who subsequently did not respond well to tricyclic antidepressants. These findings suggest that, even as late as six hours into a night of sleep, significant differences among depressed patients are present, based on treatment responder groups. Furthermore, a reevaluation of the previous emphasis on REM abnormalities in the first hour or two of the night may be indicated.

Author Affiliations
From the Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine.

Footnotes
Accepted for publication Oct 7, 1981.

Reprint requests to Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15261 (Dr Kupfer).

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