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Robert M. Cohen, MD, PhD; Herbert Weingartner, PhD; Sheila A. Smallberg; David Pickar, MD; Dennis L. Murphy, MD

Arch Gen Psychiatry. 1982;39(5):593-597.

Abstract
• Motor performance and cognitive function were examined in depressed patients and controls. Increasing severity of depression was strongly associated with decrements in performance in both motor and memory tasks. Greatest depressionrelated impairment was found on those cognitive and motor tasks that required sustained effort. We discuss these results in terms of a generalized deficit in the central motivational state of depressed individuals.

Author Affiliations
From the Clinical Neuropharmacology Branch (Drs Cohen and Murphy), the Laboratory of Psychology and Psychopathology (Dr Weingartner and Ms Smallberg), and the Biological Psychiatry Branch (Dr Pickar), National Institute of Mental Health, Bethesda, Md.

Footnotes
Accepted for publication Aug 24, 1981.

Reprint requests to Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, MD 20205 (Dr Cohen).

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