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A Distinct Subgroup?

Kenneth S. Kendler, MD; Peter Hays, MB, FRCP(C)

Arch Gen Psychiatry. 1982;39(6):643-647.

Abstract
• This study examines whether the presence of premorbid inferiority feelings (PIFs) defines a distinct subgroup of schizophrenia. Of 122 clinically diagnosed schizophrenics, 93% of whom met DSM-III criteria for schizophrenic disorder, 31 were found to have PIFs. By family history, schizophrenia was significantly less common in first-degree relatives of schizophrenics with (1.5%) than without (9.1%) PIFs, while affective disorders were equally common in both groups of relatives. Compared with schizophrenics without PIFs, schizophrenics with PIFs were significantly more likely to have been in a stressful environment at the onset of their disorder, to have an embarrassing physical handicap, to be less severely thought-disordered, and to have a lower rate of relapse on follow-up. From a genetic, etiologic, symptomatic, and prognostic perspective, the presence of PIFs may define a distinct subgroup of schizophrenia.

Author Affiliations
From the Schizophrenia Biologic Research Center and Department of Psychiatry, Bronx Veterans Administration Medical Center, Mt Sinai School of Medicine, Bronx, NY (Dr Kendler); and the Department of Psychiatry, University of Alberta, Edmonton (Dr Hays).

Footnotes
Accepted for publication Sept 21, 1981.

Reprint requests to Department of Psychiatry, Bronx Veterans Administration Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468 (Dr Kendler).

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