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Its Occurrence at Hospital Admission and Seven Weeks Later

Martin Harrow, PhD; Linda S. Grossman, MA; Marshall L. Silverstein, PhD; Herbert Y. Meltzer, MD

Arch Gen Psychiatry. 1982;39(6):665-671.

Abstract
• To evaluate the extent and persistence of thought pathology in manic patients, 113 manic, schizophrenic, and nonpsychotic patients were assessed at the acute phase, and a subsample was reevaluated seven weeks later. Another subsample of 55 patients was assessed medication free at the acute phase. Three major indices of thought disorder were used. The data indicate that (1) most hospitalized manics are severely thought disordered; (2) hospitalized manics are as thought disordered as schizophrenics; (3) unmedicated manics are as severely thought disordered as unmedicated schizophrenics; (4) both manics' and schizophrenics' thought disorders improve after the acute phase; (5) even after the acute phase, some manics show severe thought pathology. The results support formulations that thought disorder is not unique to schizophrenia. Some factors involved in manic and schizophrenic thought pathology are similar. There may be a general psychosis factor that cuts across psychotic diagnoses.

Author Affiliations
From the Illinois State Psychiatric Institute (Drs Harrow, Silverstein, and Meltzer and Ms Grossman), the Michael Reese Hospital and Medical Center (Drs Harrow and Silverstein and Ms Grossman), and the Department of Psychiatry, University of Chicago (Drs Harrow, Silverstein, and Meltzer), Chicago.

Footnotes
Accepted for publication Aug 24, 1981.

Reprint requests to Michael Reese Hospital and Medical Center, 29th St and Ellis Ave, Chicago, IL 60616 (Dr Harrow).

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