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I. Fluid Volume

Terry L. Jernigan, PhD; Leslie M. Zatz, MD; James A. Moses, Jr, PhD; Philip A. Berger, MD

Arch Gen Psychiatry. 1982;39(7):765-770.

Abstract
• Recent findings of enlarged ventricles and sulcal widening in the computed tomographic (CT) scans of schizophrenic subjects have raised questions about the etiology and treatment of this disorder. Measures obtained from computerized analyses of CT scans of 30 schizophrenic and 33 normal subjects showed no significant difference between the groups in ventricular or sulcal fluid volumes. The discrepancy between our findings and those of other investigators may have been due to different measurement techniques or to differences in the samples. A second study was undertaken to examine the first possibility. Its results suggest that our findings and those based on measurements of planimetric ventricle-brain ratios (VBRs) are highly correlated, but that VBRs from one study may not be compared with those in another to establish population differences. Differences in patient samples appear to constitute an important source of discrepancy in CT findings.

Author Affiliations
From the Psychiatry (Drs Jernigan and Berger), Radiology (Dr Zatz), and Psychology (Dr Moses) Services, Palo Alto (Calif) Veterans Administration Medical Center and the Departments of Psychiatry (Drs Berger and Moses) and Radiology (Dr Zatz), Stanford (Calif) University School of Medicine.

Footnotes
Accepted for publication March 11, 1982.

Reprint requests to Psychiatry (116 A3), VA Medical Center, 3801 Miranda Ave, Palo Alto, CA 94304 (Dr Jernigan).

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