Response to Phenelzine and Amitriptyline in Subtypes of Outpatient Depression

doi:10.1001/archpsyc.1982.04290090035008

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Vol. 39 No. 9, September 1982

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Response to Phenelzine and Amitriptyline in Subtypes of Outpatient Depression

Eugene S. Paykel, MD, FRCP, FRCPEd, FRCPsych; Peter R. Rowan, MB, BS, MRCPsych; Robert R. Parker, MB, ChB, MPhil, MRCPsych, DObst RCOG; Ashok V. Bhat, MSc, FSS

Arch Gen Psychiatry. 1982;39(9):1041-1049.

Abstract

• Outpatients with depression and mixed anxiety-depressionwere treated for six weeks with phenelzine sulfate, amitriptylinehydrochloride, or placebo in a controlled trial. Both activedrugs were superior to placebo and were closely comparable inefficacy. Interactions were examined between drug response andclassifications based on three different usages of the termatypical depression: additional anxiety or phobic symptoms,atypical functional shift, and nonendogenous depression. Someadditional related classifications were also included. Therewas a tendency for phenelzine to have stronger effects in patientswith additional anxiety and without evidence of chronic characterologicaldepression. However, interactions were relatively few. Thesefindings suggest that the two classes of antidepressant affectsimilar clinical subgroups within the outpatient depressivespectrum, with only relatively weak differences.

Author Affiliations

From the Department of Psychiatry, St George's Hospital Medical School, London. Dr Parker is now with the Department of Psychiatry, Trinity College, Dublin.

Footnotes

Accepted for publication Jan 4, 1982.

Reprints not available.

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