You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


Advertisement

ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | RSS | Access Rights | Sign In


  Vol. 39 No. 9, September 1982 TABLE OF CONTENTS
  Online Only
 •  Online First Table of
Contents
  ARTICLES
 •Online Features
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (146)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Delicious Add to Digg Add to Facebook Add to Reddit Add to Technorati Add to Twitter What's this?

Lithium Carbonate and Imipramine in the Prophylaxis of Unipolar and Bipolar II Illness

A Prospective, Placebo-Controlled Comparison

John M. Kane, MD; Frederick M. Quitkin, MD; Arthur Rifkin, MD; Jorge R. Ramos-Lorenzi, MD; Devdutt D. Nayak, MD; Alfreda Howard, MA

Arch Gen Psychiatry. 1982;39(9):1065-1069.


Abstract



• Twenty-seven patients with recurrent unipolar depression and 22 with bipolar II illness in remission for at least six months were randomly assigned on a double-blind basis to treatment regimens using lithium carbonate, imipramine hydrochloride, lithium carbonate plus imipramine, or placebo. Lithium carbonate was found to help prevent depressive relapse among patients with unipolar disease, and relapse of any type among those with bipolar II disease. No effect or interaction of imipramine was found in either group. These results add to a growing body of data that suggest the usefulness of lithium carbonate in the prophylaxis of unipolar depressive illness. The relative usefulness of lithium carbonate and imipramine requires further study.



Author Affiliations



From Long Island Jewish-Hillside Medical Center, Glen Oaks, NY (Drs Kane, Ramos-Lorenzi, and Nayak and Ms Howard), New York State Psychiatric Institute (Dr Quitkin), and Mount Sinai Medical Center (Dr Rifkin), New York.


Footnotes



Accepted for publication Feb 1, 1982.

Reprint requests to Long Island Jewish-Hillside Medical Center, Glen Oaks, NY 11004 (Dr Kane).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Meta-Analysis of Relapse Prevention Antidepressant Trials in Depressive Disorders
Glue et al.
Aust N Z J Psychiatry 2010;44:697-705.
ABSTRACT | FULL TEXT  

Pharmacological interventions for the prevention of relapse in bipolar disorder: a systematic review of controlled trials
Beynon et al.
J Psychopharmacol 2009;23:574-591.
ABSTRACT  

Lithium in maintenance therapy for bipolar disorder
Young and Newham
J Psychopharmacol 2006;20:17-22.
ABSTRACT  

Australian and New Zealand Clinical Practice Guidelines for the Treatment of Bipolar Disorder
Royal Australian And New Zealand College Of Psychi
Aust N Z J Psychiatry 2004;38:280-305.
ABSTRACT | FULL TEXT  

Suicide Risk in Bipolar Disorder During Treatment With Lithium and Divalproex
Goodwin et al.
JAMA 2003;290:1467-1473.
ABSTRACT | FULL TEXT  

Clinical importance of long-term antidepressant treatment
HIRSCHFELD
Br. J. Psychiatry 2001;179:s4-s8.
ABSTRACT | FULL TEXT  

Continuation and maintenance therapy in depression
Paykel
Br Med Bull 2001;57:145-159.
ABSTRACT | FULL TEXT  

Pharmacologic Treatment of Bipolar Disorder Through the Life Cycle
Jackson
Journal of Pharmacy Practice 1996;9:95-103.
ABSTRACT  

Switching From 'Unipolar' to Bipolar II: An 11-Year Prospective Study of Clinical and Temperamental Predictors in 559 Patients
Akiskal et al.
Arch Gen Psychiatry 1995;52:114-123.
ABSTRACT  

The long-term management of depression
Lane
J Psychopharmacol 1995;9:191-198.
ABSTRACT  

Prophylaxis in recurrent unipolar depression: a new indication for treatment studies
Montgomery
J Psychopharmacol 1989;3:47-53.
ABSTRACT  

Lithium in Depression: A Review of the Antidepressant and Prophylactic Effects of Lithium
Johnson
Aust N Z J Psychiatry 1987;21:356-365.
ABSTRACT  

Drug Therapy in the Prevention of Recurrences in Unipolar and Bipolar Affective Disorders: Report of the NIMH Collaborative Study Group Comparing Lithium Carbonate, Imipramine, and a Lithium Carbonate-Imipramine Combination
Prien et al.
Arch Gen Psychiatry 1984;41:1096-1104.
ABSTRACT  

More on Combination Antidepressant Therapy
Arch Gen Psychiatry 1984;41:527-528.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | PHYSICIAN JOBS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1982 American Medical Association. All Rights Reserved.